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April 29, 2022 – Amid all the attention this month buy kamagra online uk to actor Johnny Depp’s $50 million lawsuit against ex-wife Amber Heard, a psychological term has entered the public’s lexicon. Histrionic personality disorder.Depp says that an op-ed Heard wrote in 2018 hurt his career, and he’s suing for defamation.The term was used in court during the testimony of Shannon Curry, PsyD, a clinical buy kamagra online uk and forensic psychologist in California and Hawaii, who carried out a psychological evaluation of Heard and said that she met with Heard for 12 hours.Curry testified that Heard has both borderline personality disorder and histrionic personality disorder. Heard has said she has posttraumatic stress disorder.Due to her condition, Heard is very concerned with buy kamagra online uk image, prone to cruelty and blaming others, and unable to admit responsibility for doing something wrong, Curry testified, as reported in Newsweek.So what exactly is histrionic personality disorder, and how does it differ from the other, better-known personality disorders, such as paranoid, narcissistic, or obsessive-compulsive?. Histrionic personality disorder – histrionic means overly theatrical or melodramatic – tends to be more common in women, can be learned or inherited, and comes with “intense, unstable emotions and distorted self-images,” according to the Cleveland Clinic.And those with the disorder tend to behave dramatically, rely on other people’s buy kamagra online uk approval to bolster their self-esteem, and have an “overwhelming desire to be noticed.”Histrionic personality disorder is far less commonly diagnosed than narcissistic or borderline personality disorder, says Jessica January Behr, PsyD, a licensed psychologist in New York City.“The criteria for the disorder is probably much more commonly seen than diagnosed,” she says.

€œTo diagnose someone with histrionic personality disorder, a person has to meet five out of nine very specific criteria.”These nine criteria include being uncomfortable unless you’re the center of attention, your emotions shifting rapidly, acting very dramatically – as though performing before an audience – with exaggerated emotions and expressions yet appearing to lack sincerity, and constantly seeking reassurance or approval, according to the Cleveland Clinic.Ultimately, this disorder is a serious one, and the label shouldn’t be used unless a mental health expert who has evaluated you and performed certain diagnostic buy kamagra online uk tests confirms it. For treatment, people with the disorder will generally seek counseling to uncover the motivations and buy kamagra online uk fears associated with their thoughts and behavior, and the counselor will help the person learn to relate to others in a more positive way.A health care professional might also prescribe medication to treat the depression and anxiety that often come with this disorder, according to the Cleveland Clinic.“It’s good that people are learning about this psychological term, but it’s important to avoid making an armchair diagnosis,” Behr says. €œWe also have to be careful not to conflate ‘dramatic’ and ‘histrionic.’ To have histrionic personality disorder requires certain criteria to be met, and this isn’t a term to be used lightly.”.

April 29, 2022 – Amid all the attention this month to actor Johnny Depp’s $50 million lawsuit against ex-wife Amber Heard, a kamagra oral jelly buy online psychological term has entered the public’s lexicon. Histrionic personality disorder.Depp says that an op-ed Heard wrote in 2018 hurt his career, and he’s suing for defamation.The term was used in court during the testimony of Shannon Curry, PsyD, a clinical and forensic psychologist in California and Hawaii, who carried out a psychological evaluation of Heard and said that she met with Heard for 12 hours.Curry testified that Heard has both borderline personality disorder and histrionic personality disorder kamagra oral jelly buy online. Heard has said she has posttraumatic stress disorder.Due to her condition, Heard is very concerned with image, prone to cruelty and blaming others, and unable to admit responsibility for doing something wrong, Curry testified, as reported in Newsweek.So what exactly is histrionic personality disorder, and how does it differ from the other, better-known kamagra oral jelly buy online personality disorders, such as paranoid, narcissistic, or obsessive-compulsive?.

Histrionic personality disorder – histrionic means overly theatrical or melodramatic – tends to be more common in women, can be learned or inherited, and comes with “intense, unstable emotions and distorted self-images,” according to the Cleveland Clinic.And those with the disorder tend to behave dramatically, rely on other people’s approval to bolster their self-esteem, kamagra oral jelly buy online and have an “overwhelming desire to be noticed.”Histrionic personality disorder is far less commonly diagnosed than narcissistic or borderline personality disorder, says Jessica January Behr, PsyD, a licensed psychologist in New York City.“The criteria for the disorder is probably much more commonly seen than diagnosed,” she says. €œTo diagnose someone with histrionic personality disorder, a person has to meet five out of nine kamagra oral jelly buy online very specific criteria.”These nine criteria include being uncomfortable unless you’re the center of attention, your emotions shifting rapidly, acting very dramatically – as though performing before an audience – with exaggerated emotions and expressions yet appearing to lack sincerity, and constantly seeking reassurance or approval, according to the Cleveland Clinic.Ultimately, this disorder is a serious one, and the label shouldn’t be used unless a mental health expert who has evaluated you and performed certain diagnostic tests confirms it. For treatment, people with the disorder will generally seek counseling to uncover the motivations and fears associated with their thoughts and behavior, and the counselor will help the person learn to relate to others in a more positive way.A health care professional might also prescribe medication to treat the depression and anxiety that kamagra oral jelly buy online often come with this disorder, according to the Cleveland Clinic.“It’s good that people are learning about this psychological term, but it’s important to avoid making an armchair diagnosis,” Behr says.

€œWe also have to be careful not to conflate ‘dramatic’ and ‘histrionic.’ To have histrionic personality disorder requires certain criteria to be met, and this isn’t a term to be used lightly.”.

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This funding will help kamagra oral jelly buy online provide the support they need on the long road to recovery,” Ms Cooke said. The initiative will be delivered by Healthy North Coast through the PHN Program and in collaboration with the Northern NSW Local Health District. Healthy North Coast Chief Executive Officer Julie Sturgess said the program will focus on young people, older people and Aboriginal and Torres Strait Islander people in the NSW local government areas of Lismore, Richmond Valley, Tweed, Ballina, Byron, Kyogle and Clarence Valley. €œThese communities are most at risk of kamagra oral jelly buy online poorer outcomes following natural disasters, but they also know best what they need to get back on their feet,” Ms Sturgess said. €œFor that reason, development of grant proposals and delivery of programs will be coordinated locally to enable tailored, community-led solutions.” Under the Community Wellbeing and Resilience Flood Recovery Grants program a total of $5 million will be available over 3 years and will be released in stages.

Funding will be allocated to selected proposals with a budget of $100,000 - $200,000 per year, and multi-year projects will be considered. Healthy North kamagra oral jelly buy online Coast is inviting proposals for the following eligible community-led activities or services. Trauma-based education programs. Training and education programs such as trauma education or personal resilience programs, that promote trauma-informed principles and practices.Social and emotional wellbeing. Clinical or psychosocial kamagra oral jelly buy online trauma-informed interventions that improve wellbeing and increase emotional resilience.Cultural connection.

Activities that strengthen cultural connection or build or share Indigenous knowledge or practices. These initiatives must be delivered by Aboriginal people or organisations.Applications for grants are now open, and can be submitted online..

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During a four-year period from 2013-2017, the researchers analyzed patient data from the Johns Hopkins electronic medical record system (Epic) of 487,104 black women ages 18 and over. The prevalence of those with fibroids was kamagra jelly for sale compared in patients with and without CCCA. Overall, the researchers found that 13.9 percent of women with CCCA also had a history of uterine fibroids compared to only 3.3 percent of black women without the condition. In absolute numbers, out of the 486,000 women who were reviewed, 16,212 had fibroids.Within that population, 447 had CCCA, of which 62 had fibroids. The findings translate to a fivefold increased risk of kamagra jelly for sale uterine fibroids in women with CCCA, compared to age, sex and race matched controls.

Aguh cautions that their study does not suggest any cause and effect relationship, or prove a common cause for both conditions. €œThe cause of the link between kamagra jelly for sale the two conditions remains unclear,” she says. However, the association was strong enough, she adds, to recommend that physicians and patients be made aware of it. Women with this type of scarring kamagra jelly for sale alopecia should be screened not only for fibroids, but also for other disorders associated with excess fibrous tissue, Aguh says. An estimated 70 percent of white women and between 80 and 90 percent of African-American women will develop fibroids by age 50, according to the NIH, and while CCCA is likely underdiagnosed, some estimates report a prevalence of rates as high as 17 percent of black women having this condition.

The other authors on this paper kamagra jelly for sale were Ginette A. Okoye, M.D. Of Johns Hopkins and Yemisi Dina of Meharry Medical College.Credit. The New England Journal of Medicine Share Fast Facts This study clears up how big kamagra jelly for sale an effect the mutational burden has on outcomes to immune checkpoint inhibitors across many different cancer types. - Click to Tweet The number of mutations in a tumor’s DNA is a good predictor of whether it will respond to a class of cancer immunotherapy drugs known as checkpoint inhibitors.

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In contrast, the most common type of colorectal cancer has moderate mutational burden, yet responds poorly to checkpoint inhibitors for reasons that are still unclear. Yarchoan notes that these findings could help guide clinical trials to test checkpoint inhibitors on cancer kamagra jelly for sale types for which these drugs haven’t yet been tried. Future studies might also focus on finding ways to prompt cancers with low mutational burdens to behave like those with higher mutational burdens so that they will respond better to these therapies. He and his colleagues plan to extend this line of research by investigating whether mutational burden might be a good predictor of whether cancers in individual patients might respond well to this class of immunotherapy drugs kamagra jelly for sale. €œThe end goal is precision medicine—moving beyond what’s true for big groups of patients to see whether we can use this information to help any given patient,” he says.

Yarchoan receives funding from the Norman kamagra jelly for sale &. Ruth Rales Foundation and the Conquer Cancer Foundation. Through a licensing agreement with Aduro Biotech, Jaffee has the potential to receive royalties in the future..

Credit http://commanddeliverysystems.com/locations-2/ kamagra oral jelly buy online. IStock Share Fast Facts New @HopkinsMedicine study finds African-American women with common form of hair loss at increased risk of uterine fibroids - Click to Tweet New study in @JAMADerm shows most common form of alopecia (hair loss) in African-American women associated with higher risks of uterine fibroids - Click to Tweet In a study of medical records gathered on hundreds of thousands of African-American women, Johns Hopkins researchers say they have evidence that women with a common form of hair loss have an increased chance of developing uterine leiomyomas, or fibroids.In a report on the research, published in the December 27 issue of JAMA Dermatology, the researchers call on physicians who treat women with central centrifugal cicatricial alopecia (CCCA) to make patients aware that they may be at increased risk for fibroids and should be screened for the condition, particularly if they have symptoms such as heavy bleeding and pain. CCCA predominantly kamagra oral jelly buy online affects black women and is the most common form of permanent alopecia in this population.

The excess scar tissue that forms as a result of this type of hair loss may also explain the higher risk for uterine fibroids, which are characterized by fibrous growths in the lining of the womb. Crystal Aguh, M.D., assistant professor of dermatology at the Johns Hopkins University School of Medicine, says the scarring associated with CCCA is similar to the scarring associated with excess fibrous tissue elsewhere in the body, a situation that may explain why women with this type of hair loss are at a higher risk for fibroids.People of African descent, she notes, are more prone to develop other disorders of abnormal scarring, termed fibroproliferative disorders, such as keloids (a type of raised scar after trauma), scleroderma (an autoimmune disorder marked by thickening of the skin as kamagra oral jelly buy online well as internal organs), some types of lupus and clogged arteries. During a four-year period from 2013-2017, the researchers analyzed patient data from the Johns Hopkins electronic medical record system (Epic) of 487,104 black women ages 18 and over.

The prevalence of those with fibroids kamagra oral jelly buy online was compared in patients with and without CCCA. Overall, the researchers found that 13.9 percent of women with CCCA also had a history of uterine fibroids compared to only 3.3 percent of black women without the condition. In absolute numbers, out of the 486,000 women who were reviewed, 16,212 had fibroids.Within that population, 447 had CCCA, of which 62 had fibroids.

The findings translate to a fivefold increased risk of uterine fibroids in women with CCCA, compared to age, sex and race matched controls kamagra oral jelly buy online. Aguh cautions that their study does not suggest any cause and effect relationship, or prove a common cause for both conditions. €œThe cause of kamagra oral jelly buy online the link between the two conditions remains unclear,” she says.

However, the association was strong enough, she adds, to recommend that physicians and patients be made aware of it. Women with this type of scarring alopecia should be screened not only for fibroids, but also kamagra oral jelly buy online for other disorders associated with excess fibrous tissue, Aguh says. An estimated 70 percent of white women and between 80 and 90 percent of African-American women will develop fibroids by age 50, according to the NIH, and while CCCA is likely underdiagnosed, some estimates report a prevalence of rates as high as 17 percent of black women having this condition.

The other authors on this paper were Ginette A kamagra oral jelly buy online. Okoye, M.D. Of Johns Hopkins and Yemisi Dina of Meharry Medical College.Credit.

The New England Journal of Medicine Share kamagra oral jelly buy online Fast Facts This study clears up how big an effect the mutational burden has on outcomes to immune checkpoint inhibitors across many different cancer types. - Click to Tweet The number of mutations in a tumor’s DNA is a good predictor of whether it will respond to a class of cancer immunotherapy drugs known as checkpoint inhibitors. - Click to Tweet The kamagra oral jelly buy online “mutational burden,” or the number of mutations present in a tumor’s DNA, is a good predictor of whether that cancer type will respond to a class of cancer immunotherapy drugs known as checkpoint inhibitors, a new study led by Johns Hopkins Kimmel Cancer Center researchers shows.

The finding, published in the Dec. 21 New England Journal of Medicine, could be used to guide kamagra oral jelly buy online future clinical trials for these drugs. Checkpoint inhibitors are a relatively new class of drug that helps the immune system recognize cancer by interfering with mechanisms cancer cells use to hide from immune cells.

As a result, the drugs cause the immune system to fight cancer in the same way that it would fight an . These medicines have had remarkable success in treating some types of cancers kamagra oral jelly buy online that historically have had poor prognoses, such as advanced melanoma and lung cancer. However, these therapies have had little effect on other deadly cancer types, such as pancreatic cancer and glioblastoma.

The mutational burden of certain tumor types has previously been kamagra oral jelly buy online proposed as an explanation for why certain cancers respond better than others to immune checkpoint inhibitors says study leader Mark Yarchoan, M.D., chief medical oncology fellow. Work by Dung Le, M.D., associate professor of oncology, and other researchers at the Johns Hopkins Kimmel Cancer Center and its Bloomberg~Kimmel Cancer Institute for Cancer Immunotherapy showed that colon cancers that carry a high number of mutations are more likely to respond to checkpoint inhibitors than those that have fewer mutations. However, exactly how big an effect the mutational burden has on outcomes to kamagra oral jelly buy online immune checkpoint inhibitors across many different cancer types was unclear.

To investigate this question, Yarchoan and colleagues Alexander Hopkins, Ph.D., research fellow, and Elizabeth Jaffee, M.D., co-director of the Skip Viragh Center for Pancreas Cancer Clinical Research and Patient Care and associate director of the Bloomberg~Kimmel Institute, combed the medical literature for the results of clinical trials using checkpoint inhibitors on various different types of cancer. They combined these findings with data on the mutational burden of thousands of tumor samples from patients kamagra oral jelly buy online with different tumor types. Analyzing 27 different cancer types for which both pieces of information were available, the researchers found a strong correlation.

The higher a cancer type’s mutational burden tends to be, the more likely it is to respond to checkpoint inhibitors. More than half of the differences in how well cancers responded to immune checkpoint inhibitors could be explained kamagra oral jelly buy online by the mutational burden of that cancer. €œThe idea that a tumor type with more mutations might be easier to treat than one with fewer sounds a little counterintuitive.

It’s one of those things that doesn’t sound kamagra oral jelly buy online right when you hear it,” says Hopkins. €œBut with immunotherapy, the more mutations you have, the more chances the immune system has to recognize the tumor.” Although this finding held true for the vast majority of cancer types they studied, there were some outliers in their analysis, says Yarchoan. For example, Merkel cell cancer, kamagra oral jelly buy online a rare and highly aggressive skin cancer, tends to have a moderate number of mutations yet responds extremely well to checkpoint inhibitors.

However, he explains, this cancer type is often caused by a kamagra, which seems to encourage a strong immune response despite the cancer’s lower mutational burden. In contrast, the most common type of colorectal cancer has moderate mutational burden, yet responds poorly to checkpoint inhibitors for reasons that are still unclear. Yarchoan notes that these findings could help guide clinical trials to test checkpoint inhibitors on kamagra oral jelly buy online cancer types for which these drugs haven’t yet been tried.

Future studies might also focus on finding ways to prompt cancers with low mutational burdens to behave like those with higher mutational burdens so that they will respond better to these therapies. He and his colleagues plan to extend this line of research by investigating whether mutational kamagra oral jelly buy online burden might be a good predictor of whether cancers in individual patients might respond well to this class of immunotherapy drugs. €œThe end goal is precision medicine—moving beyond what’s true for big groups of patients to see whether we can use this information to help any given patient,” he says.

Yarchoan receives funding from the Norman &. Ruth Rales Foundation and the Conquer Cancer Foundation. Through a licensing agreement with Aduro Biotech, Jaffee has the potential to receive royalties in the future..